Identification of Biomarkers for Skin Disease
Skin is the body’s largest organ and provides an innate barrier against harmful agents encountered in the environment. Whilst the outer dermal layer is inert, the internal structure is comprised of complex cellular networks providing immunological surveillance against chemical and biological hazards.
As with all organs, disease can be manifested through internal mechanisms or in response to external stress. Innate skin disorders include psoriasis, eczema and keloid scarring. Exogenous causes include disease-related rashes and contact dermatitis caused by direct contact between skin and irritant compounds such as cleaning agents, natural irritants, precious metals and synthetic materials.
Proteome Sciences has initiated a program to identify potential biomarkers for the management of skin disorders based on cellular models of exposure to chemical allergens and to date has identified over 100 novel biomarkers that reflect skin sensitizers/allergens. Whilst directed at the development of replacement testing of chemical safety, the individual proteins so far identified and the biological pathways they are involved with may represent useful markers for the clinical management of skin disease.
We are currently looking for partners, particularly those with validated tissue models to develop this technology further.
Please Click on the Link below to download the PS Poster Presented at the 2012 Society of Toxicology Annual Meeting:
Protein Biomarker Profiles Discriminate between Sensitizing and Irritating Chemicals in Cell-Based Assays