Publications Publications

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Combined tissue and fluid proteomics with Tandem Mass Tags to identify low abundant protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study
TMTcalibrator™ tissue-enhanced fluid proteomics

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Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidate
TMTcalibrator™ tissue-enhanced fluid proteomics

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Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS
Tandem Mass Tag® Protein and Peptide Labeling

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Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans
Tandem Mass Tag® Protein and Peptide Labeling

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Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses.
Tandem Mass Tag® Protein and Peptide Labeling

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Low-pH Solid-Phase Amino Labeling of Complex Peptide Digests with TMTs Improves Peptide Identification Rates for Multiplexed Global Phosphopeptide Analysis.
Tandem Mass Tag® Protein and Peptide Labeling

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Quantitation of protein post-translational modifications using isobaric tandem mass tags.
Tandem Mass Tag® Protein and Peptide Labeling

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Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets.
SysQuant® global phosphoproteomics

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Isobaric tagging-based selection and quantitation of cerebrospinal fluid tryptic peptides with reporter calibration curves.
TMTcalibrator™ tissue-enhanced fluid proteomics

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Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

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Tyrosine phosphorylation of tau by the SRC family kinases Lck and Fyn.

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Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.

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The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

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p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

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ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.

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Reversible cysteine-targeted oxidation of proteins during renal oxidative stress.

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In-depth profiling of the peripheral blood mononuclear cells proteome for clinical blood proteomics
TMT®MS2 Broadest Coverage Workflow

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Protein expression profiles of chemo-resistant mixed phenotype liver tumors using laser microdissection and LC-MS/MS proteomics

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A global proteomic study identifies distinct pathological features of IgG4-related and primary sclerosing cholangitis.

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Tubulin β-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma.

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Comparison of the nuclear proteomes of mammary epithelial cells at different stages of functional differentiation.

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Proteomics for brain disorders-the promise for biomarkers.

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Post-translational modifications in Alzheimer's disease and the potential for new biomarkers.

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Comparison of a protein-level and peptide-level labeling strategy for quantitative proteomics of synaptosomes using isobaric tags.

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Identification of proteins of Neisseria meningitidis induced under iron-limiting conditions using the isobaric tandem mass tag (TMT) labeling approach.
Tandem Mass Tag® Protein and Peptide Labeling

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Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion.

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beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.

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An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer's disease.
Biomarker Discovery

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Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags.
Biomarker Discovery

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Proteome-based plasma biomarkers for Alzheimer's disease.
Biomarker Discovery

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Plasma proteins predict conversion to dementia from prodromal disease.
Biomarker Discovery

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AddNeuroMed-the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.
Biomarker Discovery

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Plasma based markers of [11C] PiB-PET brain amyloid burden.
Biomarker Discovery

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Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease.
Biomarker Discovery

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Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease.
Biomarker Discovery
SRM Assay Development

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Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.

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Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.

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Evaluation of absolute peptide quantitation strategies using selected reaction monitoring.
SRM Assay Development

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Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
SRM Assay Development

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Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
SRM Assay Development

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Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.
SRM Assay Development

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Candidate verification of iron-regulated Neisseria meningitidis proteins using isotopic versions of tandem mass tags (TMT) and single reaction monitoring.

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