TMT®SRM Assay
TMT®SRM Assay
Development Services

The Fast Route to Biomarker Panel Validation

Seamless transition from TMT® Enabled Biomarker Discovery to Validation Particularly Suited to Panels Including Modified Peptides

TMT®SRM is a targeted assay format that enables the rapid validation of biomarker candidates and is both faster and less expensive than other approaches. Particularly suited to candidates identified in TMT® discovery workflows, TMT®SRM enables the routine measurement of panels of between 5 and 50 proteins in a range of body fluids (plasma, CSF) and cell culture supernatants. Our TMT®SRM assay development service produces bespoke assay panels with defined performance characteristics that are suitable for routine use in large study cohorts.     

The TMT®SRM Assay Development Process:

 
Phase 1Selection of proteotypic peptides
Phase 2TMT®SRM assay development and validation
Phase 3Biomarker qualification in small cohort
Phase 4Biomarker validation in a larger cohort

TMT®SRM Offers:

Assay Development Services Include 

  • Selection of proteotypic peptides by our expert team, usually from empirical data
  • Isotopic TMT® and TSQ™ Vantage Mass Spectrometry
  • Generation of a suitable reference sample
  • Pre-determined sample collection, processing and shipment protocols
  • Comprehensive report including TMT®SRM method, assay performance characteristics and biomarker validation results

 

Case Studies

Turning Problems... Into Solutions

Targeting Markers of Neurodegeneration in CSF
Targeting Markers of Neurodegeneration in CSF
Product: TMT®SRM Assay Development
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Introducing Proteomics to Allergy Testing
Introducing Proteomics to Allergy Testing
Product: TMT®MS2 Broadest Coverage Workflow
Product: TMT®SRM Assay Development
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Characterization of Tau phosphorylation in Preclinical Models of AD
Characterization of Tau phosphorylation in Preclinical Models of AD
Product: SRM Assay Development
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Have questions about TMT®SRM Assay or other development services?
To get more information about our TMT®SRM Assay or to arrange a consultation with our scientists regarding your Biomarker Discovery project.