Proteomic Screening for Neurotoxic Effects of Pesticides and Environmental Pollutants

TMTcalibrator™ Tissue-Enhanced Fluid Proteomics
TMT®MS3 Quantitative Proteomics

Goal – Identify plasma markers of developmental neurotoxic disorders

Outcome -  >1700 novel biomarker candidates identified in discovery in different species and tissues, TMTcalibrator™ assay developed to monitor the top 136 markers in plasma

Collaborators:

  • Entro de Investigacion Principe Felipe, Valencia, Spain
  • Institute for Risk Assessment Sciences, University Utrecht, Utrecht, The Netherlands
  • Institute for Environmental Studies, VU University, Amsterdam, The Netherlands 
  • Department of Environmental Toxicology, Evolutionary Biology Center, Uppsala University, Sweden
  • Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Slovak republic
  • Norwegian Institute of Public Health, Oslo, Norway

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