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Isobaric tagging-based selection and quantitation of cerebrospinal fluid tryptic peptides with reporter calibration curves.
TMTcalibrator™ tissue-enhanced fluid proteomics

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Plasma proteins predict conversion to dementia from prodromal disease.
Biomarker Discovery

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AddNeuroMed-the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.
Biomarker Discovery

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Plasma based markers of [11C] PiB-PET brain amyloid burden.
Biomarker Discovery

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Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease.
Biomarker Discovery

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Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease.
Biomarker Discovery
SRM Assay Development

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Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.

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Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.

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Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
SRM Assay Development

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Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
SRM Assay Development

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Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidate
TMTcalibrator™ tissue-enhanced fluid proteomics

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Proteome-based plasma biomarkers for Alzheimer's disease.
Biomarker Discovery

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Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags.
Biomarker Discovery

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Tyrosine phosphorylation of tau by the SRC family kinases Lck and Fyn.

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Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.

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The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

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p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

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ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.

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Proteomics for brain disorders-the promise for biomarkers.

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Post-translational modifications in Alzheimer's disease and the potential for new biomarkers.

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Comparison of a protein-level and peptide-level labeling strategy for quantitative proteomics of synaptosomes using isobaric tags.

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beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.

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An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer's disease.
Biomarker Discovery

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Combined tissue and fluid proteomics with Tandem Mass Tags to identify low abundant protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study
TMTcalibrator™ tissue-enhanced fluid proteomics

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