Biomarker Discovery
Biomarker Discovery
Biomarkers for Precision Medicine

Measuring Proteins For Better Medicines

Specialized services to enhance discovery and validation of mechanistic biomarkers in peripheral fluids

Precision Medicine requires close integration between targeted drugs and biomarkers providing early and actionable clinical information. Ideally, such biomarkers are mechanistically related to disease and treatment mechanisms, predictive of outcome and measurable in accessible samples, typically body fluids.

For new biomarker discovery we have two key technologies to improve your chances of finding the most useful proteins in your sample matrix of choice. TMTcalibrator™  combines protein and fluid proteomics to identify tissue proteins with evidenced availability for peripheral detection. If you only have fluid samples, using TMT®MS3 with abundant protein depletion improves quantitative accuracy over other proteomics methods. Irrespective of the analytical method, our suite of bioinformatics tools simplify discovery of new biomarker candidates.

If you already have candidate biomarkers at the protein or peptide level please visit our Assay Development page to learn more about our range of targeted mass spectrometry solutions. 

Biomarker Services Selector

Our Solution

I want to discover fluid biomarkers with direct role in disease

I want to discover early diagnostic biomarkers in a body fluid

I want to discover patient stratification markers in a body fluid but don’t have tissue

I want to discover tissue biomarkers for histology

I want to validate candidate biomarkers from proteomics discovery projects

I want to routinely measure 5-50 protein biomarkers in tissue or fluid

I want to translate biomarkers from a model system to humans

To aid selection of the right tool for your particular challenge we have set out the different classes of biomarker you may need, their intended use and our recommended service product.

Applications

Type of Biomarker

Intended Use

Our Solution

Diagnostic

Early diagnosis

Differentiation of disease sub-types

Prognostic

Predicting disease progression

Guiding treatment selection

Stratification

Patient selection for trial enrolment

Guiding treatment selection

Pharmacodynamic

Monitoring of efficacy

Already have protein candidates

Validation in larger cohorts

 

Case Studies

Turning Problems...
Into Solutions

The Hunt for Early Diagnostic Biomarkers of AD
The Hunt for Early Diagnostic Biomarkers of AD
Product: TMTcalibrator™ Tissue-Enhanced Fluid Proteomics
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Clusterin Glycosylation – A Prognostic AD Plasma Biomarker
Clusterin Glycosylation – A Prognostic AD Plasma Biomarker
Product: SRM Assay Development
READ MORE
Stratification Biomarkers of MCI Conversion
Stratification Biomarkers of MCI Conversion
Product: TMT®MS3 Quantitative Proteomics
READ MORE
Have questions about Biomarker Discovery or other workflows?
Learn more about Proteome Sciences or arrange a consultation with our expert team for a customized solution to your Biomarker Discovery project.