Drug Development
Drug Development
Deeper Systems Profiling

Proteomics Taking you Beyond The Genome

Mapping protein expression and modifications that define biological processes to improve research outcomes

Developing drugs in the post-genomic era faces new challenges to enable faster regulatory approval and development of precision medicine. Proteome Sciences has developed an analytical proteomic pipeline to provide broad biological context of targets and drug mechanisms based on unbiased analysis of protein expression and phosphorylation (SysQuant®), statistical data modeling (FeaST) and a novel functional analysis tool (FAT). SysQuant® proteomics is the perfect tool to support smarter target discovery and validation, characterization of disease models and determination of complete mechanisms of action.

 Technology Selector

I am interested in seeing changes in protein phosphorylation and global expression levels

I am only interested in global protein expression levels with the widest coverage

I am only interested in global protein expression levels with the highest quantitative accuracy

Protein expression and regulation of pathway activity cannot be inferred from genomic or transcriptomic data but hold the key in understanding how new agents affect their targets and wider disease biology. Our specialized proteomics workflows can be applied across all aspects of drug development to deliver deeper insights, discover biomarker candidates and enable better decision making.

 Drug Development Technology Pipeline

Project Objective

Study Design

Our Solution

Identify New Drug Targets

Proteomic analysis of frozen tissue or cell lines from human disease

Validate Drug Targets

Proteomic analysis of tissue or cells where target is interdicted by gene silencing (functional genomics)

Characterize Experimental Models

Comparison of proteomic profiles from model tissue and human disease samples

Fully Explain Mechanism of Action

Monitor protein expression and phosphorylation to reveal changes in pathway activity in dose-dependent manner

Select Patients for Clinical Trial (oncology)

Monitoring tissue samples to demonstrate activity of target and pathways that modulate response

Translate biology into Pharmacodynamic Biomarkers

Tissue-enhanced biomarker discovery in peripheral fluids

 

Case Studies

Turning Problems...
Into Solutions

Profiling New Drug Targets for Alzheimer’s Disease
Profiling New Drug Targets for Alzheimer’s Disease
Product: SysQuant® Global Phosphoproteomics
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Stacking the Odds in Alzheimer’s Disease Drug Development
Stacking the Odds in Alzheimer’s Disease Drug Development
Product: SysQuant® Global Phosphoproteomics
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Unravelling the Mechanism of Action of Combined Targets in Melanoma
Unravelling the Mechanism of Action of Combined Targets in Melanoma
Product: SysQuant® Global Phosphoproteomics
READ MORE
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