Tandem Mass Tags (TMT)

Protein and Peptide Labeling

Tandem Mass Tag Protein and Peptide Labeling

Exclusively available through Thermo Scientific 

Proteome Sciences has a long and successful track record in discovering, validating and implementing biomarkers in many different sample types and across a diverse range of indications. At the heart of our approach is the use of the very latest and most sensitive mass spectrometry instrumentation and techniques, coupled with our own proprietary Tandem Mass Tag (TMT) that allow tighter control on analytical variability and rapid development of mass spectrometry assays for biomarker validation. TMT works like a car tracker system but only to monitor proteins and peptides.

TMT enable isobaric labeling of peptides derived from proteins extracted from cells, tissues and other biological samples for multiplexed quantitative measurement by mass spectrometry.

We design and manufacture all TMT based products in our laboratory in Frankfurt, Germany.  These TMT protein labeling reagents are used by us in house in our CRO servcies.  Kits are commercially available exclusively from Thermo Scientific.

Tandem Mass Tag (TMT) Systems

For more details on how TMT can be applied to unbiased proteomic studies pleas review this link.

Featured on The Lab Tube

Prof. Steve Gygi, Department of Cell Biology, Harvard Medical School, discusses the impact the new Thermo Scientific Orbitrap Fusion Lumos™ MS technology will have on protein quantitation, cell biology research and ultimately the evolution of drug discovery and treatment, featuring Proteome Sciences proprietary Tandem Mass Tag Technology.   View the Video Link here.

Proteomics Leadership Series by Thermo Scientific

Dr. Ian Pike, CSO of Proteome Science, describes their work on developing new approaches to stratified medicine and bringing their mass spectrometry based proteomics approaches into the clinic. For example he describes SysQuant, a hybrid proteomic/phosphoproteomic approach to stratifying mechanisms of disease in individual patients with pancreatic cancer, TMT Calibrator for low level identification of tissue derived biomarkers in body fluids and work on a CSF biomarker panel for Alzheimer’s disease. View the presentation here.