Publications
Vaccination with post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunity
Disease Area:
Authors: Sabaria Shah, Katherine W Cook, Peter Symonds, Juliane Weißer, Anne Skinner, Abdullah Al Omari, Samantha J Paston, Ian Pike, Lindy G Durrant and Victoria A Brentville
Publisher: Journal for ImmunoTherapy of Cancer 2023;11:e006966. doi: 10.1136/jitc-2023-006966
Date:
October 2023
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Disease Area:
Authors: Wittrahm R, Takalo M, Kuulasmaa T, Mäkinen PM, Mäkinen P, Končarević S, Fartzdinov V, Selzer S, Kokkola T, Antikainen L, Martiskainen H, Kemppainen S, Marttinen M, Jeskanen H, Rostalski H, Rahunen E, Kivipelto M, Ngandu T, Natunen T, Lambert JC, Tanzi RE, Kim DY, Rauramaa T, Herukka SK, Soininen H, Laakso M, Pike I, Leinonen V, Haapasalo A, Hiltunen M.
Publisher: Neurobiol Dis. 182:106140. doi: 10.1016/j.nbd.2023.106140. Epub 2023 Apr 28. PMID: 37120095.
Date:
June 2023
Cerebrospinal fluid and brain proteoforms of the granin neuropeptide Family in Alzheimer's disease.
Disease Area:
Authors: Quinn JP., Ethier EC., Novielli A., Malone A., Ramirez CE., Salloum L., Trombetta BA., Kivisäkk P., Bremang M., Selzer S., Fournier M., Das S., Xing Y., Arnold SE., Carlyle BC.
Publisher: J Am Soc Mass Spectrom doi 10.1021/jasms.2c00341
Date:
March 2023
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5
Disease Area:
Authors: Ferreira CB, Marttinen M, Coelho JE, Paldanius KMA, Takalo M, Mäkinen P, Leppänen L, Miranda-Lourenço C, Fonseca-Gomes J, Tanqueiro SR, Vaz SH, Belo RF, Sebastião AM, Leinonen V, Soininen H, Pike I, Haapasalo A, Lopes LV, de Mendonça A, Diógenes MJ, Hiltunen M.
Publisher: Neurobiol Dis.; 163:105603. doi: 10.1016/j.nbd.2021.105603. Epub 2021 Dec 24. PMID: 34954322.
Date:
February 2022
Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.
Disease Area:
Authors: Izzo NJ, Yuede CM, LaBarbera KM, Limegrover CS, Rehak C, Yurko R, Waybright L, Look G, Rishton G, Safferstein H, Hamby ME, Williams C, Sadlek K, Edwards HM, Davis CS, Grundman M, Schneider LS, DeKosky ST, Chelsky D, Pike I, Henstridge C, Blennow K, Zetterberg H, LeVine H 3rd, Spires-Jones TL, Cirrito JR, Catalano SM.
Publisher: Alzheimers Dement. 2021 Aug;17(8):1365-1382. doi: 10.1002/alz.12302. Epub 2021 Feb 8. PMID: 33559354; PMCID: PMC8349378.
Date:
August 2021
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.
Disease Area:
Authors: Panitz V, Končarević S, Sadik A, Friedel D, Bausbacher T, Trump S, Farztdinov V, Schulz S, Sievers P, Schmidt S, Jürgenson I, Jung S, Kuhn K, Pflüger I, Sharma S, Wick A, Pfänder P, Selzer S, Vollmuth P, Sahm F, von Deimling A, Heiland I, Hopf C, Schulz-Knappe P, Pike I, Platten M, Wick W, Opitz CA.
Publisher: Theranostics. 2021 Sep 3;11(19):9217-9233. doi: 10.7150/thno.60679. PMID: 34646367; PMCID: PMC8490504.
Date:
September 2021
Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders
Disease Area:
Authors: Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D, McArthur S, Pike I, Malaspina A.
Publisher: Brain Commun. 2021 Jul 9;3(3):fcab148. doi: 10.1093/braincomms/fcab148. PMID: 34396108; PMCID: PMC8361415.
Date:
July 2021
TMTpro 18plex: The expanded and complete set of TMTpro reagents for sample multiplexing
Disease Area:
Authors: Li J, Cai Z, Bomgarden RD, Pike I, Kuhn K, Rogers JC, Roberts TM, Gygi SP, Paulo JA.
Publisher: J Proteome Res. 2021 May 7;20(5):2964-2972. doi: 10.1021/acs.jproteome.1c00168. Epub 2021 Apr 26. PMID: 33900084; PMCID: PMC8210943.
Date:
May 2021
Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
Disease Area:
Authors: Eysert F, Coulon A, Boscher E, Vreulx AC, Flaig A, Mendes T, Hughes S, Grenier-Boley B, Hanoulle X, Demiautte F, Bauer C, Marttinen M, Takalo M, Amouyel P, Desai S, Pike I, Hiltunen M, Chécler F, Farinelli M, Delay C, Malmanche N, Hébert SS, Dumont J, Kilinc D, Lambert JC, Chapuis J.
Publisher: Mol Psychiatry. 2021 Oct;26(10):5592-5607. doi: 10.1038/s41380-020-00926-w. Epub 2020 Nov 3. Erratum in: Mol Psychiatry. 2021 Jan 4;: PMID: 33144711; PMCID: PMC8758496.
Date:
October 2021
TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples
Disease Area:
Authors: Li J, Van Vranken JG, Pontano Vaites L, Schweppe DK, Huttlin EL, Etienne C, Nandhikonda P, Viner R, Robitaille AM, Thompson AH, Kuhn K, Pike I, Bomgarden RD, Rogers JC, Gygi SP, Paulo JA.
Publisher: Nat Methods. 2020 Apr;17(4):399-404. doi: 10.1038/s41592-020-0781-4. Epub 2020 Mar 16. PMID: 32203386; PMCID: PMC7302421.
Date:
April 2020
Combined tissue-fluid proteomics to unravel phenotypic variability in Amyotrophic Lateral Sclerosis
Disease Area:
Authors: Leoni E, Bremang M, Mitra V, Zubiri I, Jung S, Lu CH, Adiutori R, Lombardi V, Russell C, Koncarevic S, Ward M, Pike I, Malaspina A.
Publisher: Sci Rep. 2019 Mar 14;9(1):4478. doi: 10.1038/s41598-019-40632-4. Erratum in: Sci Rep. 2020 Oct 23;10(1):18603. PMID: 30872628; PMCID: PMC6418138.
Date:
March 2019
TMTpro: Design, synthesis, and initial evaluation of a proline-based Isobaric 16-plex Tandem Mass Tag reagent set
Disease Area:
Authors: Thompson A, Wölmer N, Koncarevic S, Selzer S, Böhm G, Legner H, Schmid P, Kienle S, Penning P, Höhle C, Berfelde A, Martinez-Pinna R, Farztdinov V, Jung S, Kuhn K, Pike I.
Publisher: Anal Chem. 2019 Dec 17;91(24):15941-15950. doi: 10.1021/acs.analchem.9b04474. Epub 2019 Dec 3. PMID: 31738517.
Date:
December 2019
Quantitative proteomics of breast tumors: Tissue quality assessment to clinical biomarkers
Disease Area:
Authors: Chen Y, Britton D, Wood ER, Brantley S, Magliocco A, Pike I, Koomen JM.
Publisher: Proteomics. 2017 Mar;17(6):10.1002/pmic.201600335. doi: 10.1002/pmic.201600335. PMID: 28127872; PMCID: PMC5996774.
Date:
March 2017
Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics.
Disease Area:
Authors: Magdalinou NK, Noyce AJ, Pinto R, Lindstrom E, Holmén-Larsson J, Holtta M, Blennow K, Morris HR, Skillbäck T, Warner TT, Lees AJ, Pike I, Ward M, Zetterberg H, Gobom J.
Publisher: Parkinsonism Relat Disord. 2017 Apr;37:65-71. doi: 10.1016/j.parkreldis.2017.01.016. Epub 2017 Jan 31. PMID: 28214264.
Date:
April 2017
Interrelationship between the levels of C9orf72 and amyloid-β protein precursor and amyloid-β in human cells and brain samples
Disease Area:
Authors: S. Leskelä et al
Publisher: Journal of Alzheimer's disease 62(1):269-278 DOI: 10.3233/JAD-170362
Date:
February 2018
The proteome of neurofilament-containing protein aggregates in blood
Disease Area:
Authors: R. Adiutori et al.
Publisher: Biochemistry and Biophysics Reports 14, Pages 168-177
Date:
May 2018
Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis
Disease Area:
Authors: I. Zubiri et al.
Publisher: Molecular Neurodegeneration 13(1) DOI: 10.1186/s13024-018-0292-2
Date:
November 2018
A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology
Disease Area:
Authors:
Publisher: Science Direct
Date:
January 2019
Combined tissue and fluid proteomics with Tandem Mass Tags to identify low abundant protein biomarkers of disease in peripheral body fluid: An Alzheimer's disease case study
Disease Area:
Authors: Russell CL, Heslegrave A, Mitra V, Zetterberg H, Pocock JM, Ward MA, Pike I
Publisher: PubMed
Date:
November 2016
Comprehensive quantitative profiling of Tau and phosphorylated Tau peptides in cerebrospinal fluid by Mass Spectrometry provides new biomarker candidate
Disease Area:
Authors: Claire L. Russell, Vikram Mitra, Karl Hansson, Kaj Blennow, Johan Gobom, Henrik Zetterber, Mikko Hiltunen, Malcolm Ward and Ian Pike
Publisher: PubMed
Date:
November 2016
Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS
Disease Area:
Authors: Thompson A, Schäfer J, Kuhn K, Kienle S, Schwarz J, Schmidt G, Neumann T, Johnstone R, Mohammed AK, Hamon C.
Publisher: PubMed
Date:
April 2003
Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans
Disease Area:
Authors: Hahne H, Neubert P, Kuhn K, Etienne C, Bomgarden R, Rogers JC, Kuster B.
Publisher: PubMed
Date:
2012 Apr
Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses.
Disease Area:
Authors: McAlister GC, Huttlin EL, Haas W, Ting L, Jedrychowski MP, Rogers JC, Kuhn K, Pike I, Grothe RA, Blethrow JD, Gygi SP.
Publisher: PubMed
Date:
2012 Sep
Low-pH solid-phase amino labeling of complex peptide digests with TMTs Improves peptide identification rates for multiplexed global phosphopeptide analysis.
Disease Area:
Authors: Böhm G, Prefot P, Jung S, Selzer S, Mitra V, Britton D, Kuhn K, Pike I, Thompson AH.
Publisher: PubMed
Date:
June 2015
Quantitation of protein post-translational modifications using isobaric tandem mass tags.
Disease Area:
Authors: Liang HC, Lahert E, Pike I, Ward M.
Publisher: PubMed
Date:
2015
Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets.
Disease Area:
Authors: Britton D, Zen Y, Quaglia A, Selzer S, Mitra V, Löβner C, Jung S, Böhm G, Schmid P, Prefot P, Hoehle C, Koncarevic S, Gee J, Nicholson R, Ward M, Castellano L, Stebbing J, Zucht HD, Sarker D, Heaton N, Pike I.
Publisher: PubMed
Date:
2014 March
Isobaric tagging-based selection and quantitation of cerebrospinal fluid tryptic peptides with reporter calibration curves.
Disease Area:
Authors: Dayon L, Turck N, Kienle S, Schulz-Knappe P, Hochstrasser DF, Scherl A, Sanchez JC.
Publisher: PubMed
Date:
2010 Feb
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.
Disease Area:
Authors: Hanger DP, Byers HL, Wray S, Leung KY, Saxton MJ, Seereeram A, Reynolds CH, Ward MA, Anderton BH.
Publisher: PubMed
Date:
2017 Aug
Tyrosine phosphorylation of tau by the SRC family kinases Lck and Fyn.
Disease Area:
Authors: Scales TM, Derkinderen P, Leung KY, Byers HL, Ward MA, Price C, Bird IN, Perera T, Kellie S, Williamson R, Anderton BH, Reynolds CH.
Publisher: PubMed
Date:
2011 Jan
Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.
Disease Area:
Authors: Cuchillo-Ibanez I, Seereeram A, Byers HL, Leung KY, Ward MA, Anderton BH, Hanger DP.
Publisher: PubMed
Date:
2008 Sep
The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).
Disease Area:
Authors: Standen CL, Perkinton MS, Byers HL, Kesavapany S, Lau KF, Ward M, McLoughlin D, Miller CC.
Publisher: PubMed
Date:
2003
p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.
Disease Area:
Authors: Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS, Anderton BH, Cooper JD, Dingwall C, Leigh PN, Shaw CE, Miller CC.
Publisher: PubMed
Date:
2004 Jun
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
Disease Area:
Authors: Tudor EL, Perkinton MS, Schmidt A, Ackerley S, Brownlees J, Jacobsen NJ, Byers HL, Ward M, Hall A, Leigh PN, Shaw CE, McLoughlin DM, Miller CC.
Publisher: PubMed
Date:
2005
Reversible cysteine-targeted oxidation of proteins during renal oxidative stress.
Disease Area:
Authors: Eaton P1, Jones ME, McGregor E, Dunn MJ, Leeds N, Byers HL, Leung KY, Ward MA, Pratt JR, Shattock MJ
Publisher: PubMed
Date:
2003
In-depth profiling of the peripheral blood mononuclear cells proteome for clinical blood proteomics
Disease Area:
Authors: Končarević S, Lößner C, Kuhn K, Prinz T, Pike I, Zucht HD.
Publisher: PubMed
Date:
2014
Protein expression profiles of chemo-resistant mixed phenotype liver tumors using laser microdissection and LC-MS/MS proteomics
Disease Area:
Authors: Zen Y, Britton D, Mitra V, Brand A, Jung S, Löβner C, Ward M, Pike I, Heaton N, Quaglia A
Publisher: PubMed
Date:
2013
A global proteomic study identifies distinct pathological features of IgG4-related and primary sclerosing cholangitis.
Disease Area:
Authors: Zen Y, Britton D, Mitra V, Pike I, Heaton N, Quaglia A.
Publisher: PubMed
Date:
2015
Tubulin β-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma.
Disease Area:
Authors: Zen Y, Britton D, Mitra V, Pike I, Sarker D, Itoh T, Heaton N, Quaglia A.
Publisher: PubMed
Date:
2014
Comparison of the nuclear proteomes of mammary epithelial cells at different stages of functional differentiation.
Disease Area:
Authors: Desrivières S, Kuhn K, Müller J, Gläser M, Laria NC, Korder J, Sonnentag M, Neumann T, Schwarz J, Schäfer J, Hamon C, Groner B, Prinz T.
Publisher: PubMed
Date:
2007 June
Proteomics for brain disorders-the promise for biomarkers.
Disease Area:
Authors: Ward M, Güntert A, Campbell J, Pike I.
Publisher: PubMed
Date:
2009
Post-translational modifications in Alzheimer's disease and the potential for new biomarkers.
Disease Area:
Authors: Russell CL, Koncarevic S, Ward MA.
Publisher: PubMed
Date:
2014
Comparison of a protein-level and peptide-level labeling strategy for quantitative proteomics of synaptosomes using isobaric tags.
Disease Area:
Authors: Engmann O, Campbell J, Ward M, Giese KP, Thompson AJ.
Publisher: PubMed
Date:
2010 May
Identification of proteins of Neisseria meningitidis induced under iron-limiting conditions using the isobaric tandem mass tag (TMT) labeling approach.
Disease Area:
Authors: van Ulsen P, Kuhn K, Prinz T, Legner H, Schmid P, Baumann C, Tommassen J.
Publisher: PubMed
Date:
2009 Apr
Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion.
Disease Area:
Authors: Eaton P, Byers HL, Leeds N, Ward MA, Shattock MJ.
Publisher: PubMed
Date:
2002 Mar
beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.
Disease Area:
Authors: Ji Y1, Ferracci G, Warley A, Ward M, Leung KY, Samsuddin S, Lévêque C, Queen L, Reebye V, Pal P, Gkaliagkousi E, Seager M, Ferro A.
Publisher: PubMed
Date:
2007 May
An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer's disease.
Disease Area:
Authors: Hölttä M, Minthon L, Hansson O, Holmén-Larsson J, Pike I, Ward M, Kuhn K, Rüetschi U, Zetterberg H, Blennow K, Gobom J.
Publisher: PubMed
Date:
2015
Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags.
Disease Area:
Authors: Dayon L, Hainard A, Licker V, Turck N, Kuhn K, Hochstrasser DF, Burkhard PR, Sanchez JC.
Publisher: PubMed
Date:
2008
Proteome-based plasma biomarkers for Alzheimer's disease.
Disease Area:
Authors: Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper C, Rijsdijk F, Tabrizi SJ, Banner S, Shaw CE, Foy C, Poppe M, Archer N, Hamilton G, Powell J, Brown RG, Sham P, Ward M, Lovestone S.
Publisher: PubMed
Date:
2006 Nov
Plasma proteins predict conversion to dementia from prodromal disease.
Disease Area:
Authors: Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K, Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S.
Publisher: PubMed
Date:
2014 Nov
AddNeuroMed-the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.
Disease Area:
Authors: Lovestone S1, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund LO, Ward M; AddNeuroMed Consortium.
Publisher: PubMed
Date:
2009 Oct
Plasma based markers of [11C] PiB-PET brain amyloid burden.
Disease Area:
Authors: Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I,Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R; Alzheimers Disease Neuroimaging Initiative
Publisher: PubMed
Date:
2012
Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease.
Disease Area:
Authors: Güntert A, Campbell J, Saleem M, O'Brien DP, Thompson AJ, Byers HL, Ward MA, Lovestone S.
Publisher: PubMed
Date:
2012
Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease.
Disease Area:
Authors: Liang HC, Russell C, Mitra V, Chung R, Hye A, Bazenet C, Lovestone S, Pike I, Ward M.
Publisher: PubMed
Date:
2015 / 2016
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.
Disease Area:
Authors: Thambisetty M1, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Güntert A, Proitsi P, Powell J, Causevic M, Killick R, Lunnon K, Lynham S, Broadstock M, Choudhry F, Howlett DR, Williams RJ, Sharp SI, Mitchelmore C, Tunnard C, Leung R, Foy C, O'Brien D, Breen G, Furney SJ, Ward M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Hodges A, Murphy DG, Parkins S, Richardson JC, Resnick SM, Ferrucci L, Wong DF,Zhou Y, Muehlboeck S, Evans A, Francis PT, Spenger C, Lovestone S.
Publisher: PubMed
Date:
2010
Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.
Disease Area:
Authors: Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén A, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M, Tabrizi SJ.
Publisher: PubMed
Date:
2007
Evaluation of absolute peptide quantitation strategies using selected reaction monitoring.
Disease Area:
Authors: Campbell J, Rezai T, Prakash A, Krastins B, Dayon L, Ward M, Robinson S, Lopez M.
Publisher: PubMed
Date:
2011 Mar
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Disease Area:
Authors: Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B
Publisher: PubMed
Date:
2013
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Disease Area:
Authors: Löffler T, Flunkert S, Taub N, Schofield EL, Ward MA, Windisch M, Hutter-Paier B.
Publisher: PubMed
Date:
2012 May
Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.
Disease Area:
Authors: Floyd CN, Goodman T, Becker S, Chen N, Mustafa A, Schofield E, Campbell J, Ward M, Sharma P, Ferro A.
Publisher: PubMed
Date:
2014 Aug
Candidate verification of iron-regulated Neisseria meningitidis proteins using isotopic versions of tandem mass tags (TMT) and single reaction monitoring.
Disease Area:
Authors: Byers HL, Campbell J, van Ulsen P, Tommassen J, Ward MA, Schulz-Knappe P, Prinz T, Kuhn K.
Publisher: PubMed
Date:
2009
