Publications
Interrelationship between the Levels of C9orf72 and Amyloid-β Protein Precursor and Amyloid-β in Human Cells and Brain Samples
Authors: S. Leskelä et al
Publisher: Journal of Alzheimer's disease 62(1):269-278 DOI: 10.3233/JAD-170362
The proteome of neurofilament-containing protein aggregates in blood
Authors: R. Adiutori et al.
Publisher: Biochemistry and Biophysics Reports 14, Pages 168-177
Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis
Authors: I. Zubiri et al.
Publisher: Molecular Neurodegeneration 13(1) DOI: 10.1186/s13024-018-0292-2
A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology
Product:
SysQuant global phosphoproteomics
Authors:
Publisher: Science Direct
Date:
11 January 2019
Combined tissue and fluid proteomics with Tandem Mass Tags to identify low abundant protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study
Authors: Russell CL, Heslegrave A, Mitra V, Zetterberg H, Pocock JM, Ward MA, Pike I
Publisher: PubMed
Date:
November 2016
Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidate
Authors: Claire L. Russell, Vikram Mitra, Karl Hansson, Kaj Blennow, Johan Gobom, Henrik Zetterber, Mikko Hiltunen, Malcolm Ward and Ian Pike
Publisher: PubMed
Date:
November 2016
Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS
Product:
Tandem Mass Tag Protein and Peptide Labeling
Authors: Thompson A, Schäfer J, Kuhn K, Kienle S, Schwarz J, Schmidt G, Neumann T, Johnstone R, Mohammed AK, Hamon C.
Publisher: PubMed
Date:
2003 Apr
Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans
Product:
Tandem Mass Tag Protein and Peptide Labeling
Authors: Hahne H, Neubert P, Kuhn K, Etienne C, Bomgarden R, Rogers JC, Kuster B.
Publisher: PubMed
Date:
2012 Apr
Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses.
Product:
Tandem Mass Tag Protein and Peptide Labeling
Authors: McAlister GC, Huttlin EL, Haas W, Ting L, Jedrychowski MP, Rogers JC, Kuhn K, Pike I, Grothe RA, Blethrow JD, Gygi SP.
Publisher: PubMed
Date:
2012 Sep
Low-pH Solid-Phase Amino Labeling of Complex Peptide Digests with TMTs Improves Peptide Identification Rates for Multiplexed Global Phosphopeptide Analysis.
Product:
Tandem Mass Tag Protein and Peptide Labeling
Authors: Böhm G, Prefot P, Jung S, Selzer S, Mitra V, Britton D, Kuhn K, Pike I, Thompson AH.
Publisher: PubMed
Date:
2015 Jun
Quantitation of protein post-translational modifications using isobaric tandem mass tags.
Product:
Tandem Mass Tag Protein and Peptide Labeling
Authors: Liang HC, Lahert E, Pike I, Ward M.
Publisher: PubMed
Date:
2015
Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets.
Authors: Britton D, Zen Y, Quaglia A, Selzer S, Mitra V, Löβner C, Jung S, Böhm G, Schmid P, Prefot P, Hoehle C, Koncarevic S, Gee J, Nicholson R, Ward M, Castellano L, Stebbing J, Zucht HD, Sarker D, Heaton N, Pike I.
Publisher: PubMed
Date:
2014 March
Isobaric tagging-based selection and quantitation of cerebrospinal fluid tryptic peptides with reporter calibration curves.
Authors: Dayon L, Turck N, Kienle S, Schulz-Knappe P, Hochstrasser DF, Scherl A, Sanchez JC.
Publisher: PubMed
Date:
2010 Feb
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.
Product:
SysQuant global phosphoproteomics
Authors: Hanger DP, Byers HL, Wray S, Leung KY, Saxton MJ, Seereeram A, Reynolds CH, Ward MA, Anderton BH.
Publisher: PubMed
Date:
2017 Aug
Tyrosine phosphorylation of tau by the SRC family kinases Lck and Fyn.
Authors: Scales TM, Derkinderen P, Leung KY, Byers HL, Ward MA, Price C, Bird IN, Perera T, Kellie S, Williamson R, Anderton BH, Reynolds CH.
Publisher: PubMed
Date:
2011 Jan
Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.
Authors: Cuchillo-Ibanez I, Seereeram A, Byers HL, Leung KY, Ward MA, Anderton BH, Hanger DP.
Publisher: PubMed
Date:
2008 Sep
The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).
Authors: Standen CL, Perkinton MS, Byers HL, Kesavapany S, Lau KF, Ward M, McLoughlin D, Miller CC.
Publisher: PubMed
Date:
2003
p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.
Disease Area: CNS
Authors: Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS, Anderton BH, Cooper JD, Dingwall C, Leigh PN, Shaw CE, Miller CC.
Publisher: PubMed
Date:
2004 Jun
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
Disease Area: CNS
Authors: Tudor EL, Perkinton MS, Schmidt A, Ackerley S, Brownlees J, Jacobsen NJ, Byers HL, Ward M, Hall A, Leigh PN, Shaw CE, McLoughlin DM, Miller CC.
Publisher: PubMed
Date:
2005
Reversible cysteine-targeted oxidation of proteins during renal oxidative stress.
Authors: Eaton P1, Jones ME, McGregor E, Dunn MJ, Leeds N, Byers HL, Leung KY, Ward MA, Pratt JR, Shattock MJ
Publisher: PubMed
Date:
2003
In-depth profiling of the peripheral blood mononuclear cells proteome for clinical blood proteomics
Product:
TMT-MS2 Broadest Coverage Workflow
Authors: Končarević S, Lößner C, Kuhn K, Prinz T, Pike I, Zucht HD.
Publisher: PubMed
Date:
2014
Protein expression profiles of chemo-resistant mixed phenotype liver tumors using laser microdissection and LC-MS/MS proteomics
Authors: Zen Y, Britton D, Mitra V, Brand A, Jung S, Löβner C, Ward M, Pike I, Heaton N, Quaglia A
Publisher: PubMed
Date:
2013
A global proteomic study identifies distinct pathological features of IgG4-related and primary sclerosing cholangitis.
Disease Area: Cancer
Authors: Zen Y, Britton D, Mitra V, Pike I, Heaton N, Quaglia A.
Publisher: PubMed
Date:
2015
Tubulin β-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma.
Disease Area: Cancer
Authors: Zen Y, Britton D, Mitra V, Pike I, Sarker D, Itoh T, Heaton N, Quaglia A.
Publisher: PubMed
Date:
2014
Comparison of the nuclear proteomes of mammary epithelial cells at different stages of functional differentiation.
Disease Area: Cancer
Authors: Desrivières S, Kuhn K, Müller J, Gläser M, Laria NC, Korder J, Sonnentag M, Neumann T, Schwarz J, Schäfer J, Hamon C, Groner B, Prinz T.
Publisher: PubMed
Date:
2007 June
Proteomics for brain disorders-the promise for biomarkers.
Disease Area: CNS
Authors: Ward M, Güntert A, Campbell J, Pike I.
Publisher: PubMed
Date:
2009
Post-translational modifications in Alzheimer's disease and the potential for new biomarkers.
Disease Area: CNS
Authors: Russell CL, Koncarevic S, Ward MA.
Publisher: PubMed
Date:
2014
Comparison of a protein-level and peptide-level labeling strategy for quantitative proteomics of synaptosomes using isobaric tags.
Disease Area: CNS
Authors: Engmann O, Campbell J, Ward M, Giese KP, Thompson AJ.
Publisher: PubMed
Date:
2010 May
Identification of proteins of Neisseria meningitidis induced under iron-limiting conditions using the isobaric tandem mass tag (TMT) labeling approach.
Product:
Tandem Mass Tag Protein and Peptide Labeling
Authors: van Ulsen P, Kuhn K, Prinz T, Legner H, Schmid P, Baumann C, Tommassen J.
Publisher: PubMed
Date:
2009 Apr
Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion.
Authors: Eaton P, Byers HL, Leeds N, Ward MA, Shattock MJ.
Publisher: PubMed
Date:
2002 Mar
beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.
Disease Area: CNS
Authors: Ji Y1, Ferracci G, Warley A, Ward M, Leung KY, Samsuddin S, Lévêque C, Queen L, Reebye V, Pal P, Gkaliagkousi E, Seager M, Ferro A.
Publisher: PubMed
Date:
2007 May
An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer's disease.
Authors: Hölttä M, Minthon L, Hansson O, Holmén-Larsson J, Pike I, Ward M, Kuhn K, Rüetschi U, Zetterberg H, Blennow K, Gobom J.
Publisher: PubMed
Date:
2015
Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags.
Authors: Dayon L, Hainard A, Licker V, Turck N, Kuhn K, Hochstrasser DF, Burkhard PR, Sanchez JC.
Publisher: PubMed
Date:
2008
Proteome-based plasma biomarkers for Alzheimer's disease.
Authors: Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper C, Rijsdijk F, Tabrizi SJ, Banner S, Shaw CE, Foy C, Poppe M, Archer N, Hamilton G, Powell J, Brown RG, Sham P, Ward M, Lovestone S.
Publisher: PubMed
Date:
2006 Nov
Plasma proteins predict conversion to dementia from prodromal disease.
Authors: Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K, Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S.
Publisher: PubMed
Date:
2014 Nov
AddNeuroMed-the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.
Authors: Lovestone S1, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund LO, Ward M; AddNeuroMed Consortium.
Publisher: PubMed
Date:
2009 Oct
Plasma based markers of [11C] PiB-PET brain amyloid burden.
Authors: Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I,Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R; Alzheimers Disease Neuroimaging Initiative
Publisher: PubMed
Date:
2012
Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease.
Authors: Güntert A, Campbell J, Saleem M, O'Brien DP, Thompson AJ, Byers HL, Ward MA, Lovestone S.
Publisher: PubMed
Date:
2012
Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease.
Authors: Liang HC, Russell C, Mitra V, Chung R, Hye A, Bazenet C, Lovestone S, Pike I, Ward M.
Publisher: PubMed
Date:
2015 / 2016
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.
Disease Area: CNS
Authors: Thambisetty M1, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Güntert A, Proitsi P, Powell J, Causevic M, Killick R, Lunnon K, Lynham S, Broadstock M, Choudhry F, Howlett DR, Williams RJ, Sharp SI, Mitchelmore C, Tunnard C, Leung R, Foy C, O'Brien D, Breen G, Furney SJ, Ward M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Hodges A, Murphy DG, Parkins S, Richardson JC, Resnick SM, Ferrucci L, Wong DF,Zhou Y, Muehlboeck S, Evans A, Francis PT, Spenger C, Lovestone S.
Publisher: PubMed
Date:
2010
Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.
Disease Area: CNS
Authors: Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén A, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M, Tabrizi SJ.
Publisher: PubMed
Date:
2007
Evaluation of absolute peptide quantitation strategies using selected reaction monitoring.
Product:
SRM Assay Development
Authors: Campbell J, Rezai T, Prakash A, Krastins B, Dayon L, Ward M, Robinson S, Lopez M.
Publisher: PubMed
Date:
2011 Mar
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Authors: Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B
Publisher: PubMed
Date:
2013
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Authors: Löffler T, Flunkert S, Taub N, Schofield EL, Ward MA, Windisch M, Hutter-Paier B.
Publisher: PubMed
Date:
2012 May
Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.
Product:
SRM Assay Development
Authors: Floyd CN, Goodman T, Becker S, Chen N, Mustafa A, Schofield E, Campbell J, Ward M, Sharma P, Ferro A.
Publisher: PubMed
Date:
2014 Aug
Candidate verification of iron-regulated Neisseria meningitidis proteins using isotopic versions of tandem mass tags (TMT) and single reaction monitoring.
Authors: Byers HL, Campbell J, van Ulsen P, Tommassen J, Ward MA, Schulz-Knappe P, Prinz T, Kuhn K.
Publisher: PubMed
Date:
2009
