Notification of Interests in Shares

Last Updated November 26, 2018

(a) Directors and their interests

Name of DirectorNumber of Ordinary
Shares of 1p each
Percent of current
issued share capital
C.D.J. Pearce36,915,059 12.53
Professor W. Dawson20,372 0.01 
Roger McDowell 2,500,000 0.85
Jeremy Haigh400,0000.14
Martin Diggle*

(b) Significant Shareholders 

Name of ShareholderNumber of Ordinary
Shares of 1p each
Percent of Current
issued share capital 
Vulpes Life Science Fund64,946,73422
Helium Special Situations Fund19,212,273 6.52 
   

Notes:

-The current issued share capital of the company consists of 295,182,056 Ordinary shares of 1p each. There are 33.29% of AIM securities not in public hands.

-M.Diggle is a director and partner in Vulpes Investment Management and manages the Vulpes Life Sciences Fund which is the registered holder of 22% of Proteome Sciences' ordinary share capital as noted above.