Notification of Interests in Shares

Last Updated 29 January 2026

(a) Directors and their interests

Name of Director Number of Ordinary
Shares of 1p each
Percent of current
issued share capital
C.D.J. Pearce 36,915,059  10.53
Dr I Pike 165,583  0.05
Roger McDowell 3,400,000  0.97
Martin Diggle*
Richard Dennis 2,053,571 0.60

(b) Significant Shareholders 

Name of Shareholder Number of Ordinary
Shares of 1p each
Percent of Current
issued share capital 
Vulpes Life Science Fund 84,932,629 24.2
Spreadex Ltd 10,980,386 3.13

Notes:

-The current issued share capital of the company consists of 350,724,912 Ordinary shares of 1p each. There are 39.47% of AIM securities not in public hands.

-M. Diggle is a director and partner in Vulpes Investment Management and manages the Vulpes Life Sciences Fund which is the registered holder of 24.2% of Proteome Sciences' ordinary share capital as noted above.