Notification of Interests in Shares

Last Updated November 26, 2018

(a) Directors and their interests

Name of Director	Number of Ordinary Shares of 1p each	Percent of current issued share capital
C.D.J. Pearce	36,915,059	12.53
Professor W. Dawson	20,372	0.01
Roger McDowell	2,500,000	0.85
Jeremy Haigh	400,000	0.14
Martin Diggle*	-	-

(b) Significant Shareholders

Name of Shareholder	Number of Ordinary Shares of 1p each	Percent of Current issued share capital
Vulpes Life Science Fund	64,946,734	22
Helium Special Situations Fund	19,212,273	6.52

Notes:

-The current issued share capital of the company consists of 295,182,056 Ordinary shares of 1p each. There are 33.29% of AIM securities not in public hands.

-M.Diggle is a director and partner in Vulpes Investment Management and manages the Vulpes Life Sciences Fund which is the registered holder of 22% of Proteome Sciences' ordinary share capital as noted above.