Modern proteomics analysis by mass spectrometry provides unique insights on protein expression and post-translational modifications that regulate the majority of biological processes. Whether you are performing very early-stage basic research, or late stage drug development, our proteomics platforms provide key solutions to drive your projects forward.
Choosing the right approach for sample production, protein/PTM analysis and bioinformatics is critical in getting the most informative data and revealing deeper biological insights. With over 25 years’ experience of designing and performing unbiased whole-proteome, semi-targeted and fully-targeted methods, we can guide you through the selection process and deliver you the results you need, when you need them.
The tables below allow self-guided exploration of our services with links to the relevant service. For more detailed discussion of your specific needs, please contact us using the link below.
Technology Selector
| Cell and tissue Proteomics | |
|---|---|
| I need to map global protein expression levels with the widest coverage and highest precision | TMT LC-MS2 |
| I need to map global protein expression levels with the highest quantitative accuracy | TMT LC-MS3 |
| I need to map global protein expression levels and changes in protein post translational modifications such as phosphorylation, ubiquitinoylation etc | SysQuant |
| Fluid Proteomics | |
|---|---|
| I need to discover diagnostic/patient stratification markers in a body fluid but don’t have tissue | |
| I need to find mechanism-related biomarkers in biofluids and have cells/tissue for use as a trigger | TMTcalibrator |
| I am interested in global protein expression levels with the widest coverage of disease relevant proteins in plasma and serum |
In conjunction with Super Depletion
|
| Targeted & Bespoke Workflows | |
|---|---|
| I want to validate candidate biomarkers from proteomics discovery projects | Bespoke Targeted Assay Development |
| I want to routinely measure 5-50 protein biomarkers in tissue or fluid as a single multiplex assay | Selected Reaction Monitoring (SRM) |
| I want to translate biomarkers from a model system to humans | Parallel Reaction Monitoring (PRM) |
| I have an ELISA and I need to improve LLOQ/LOD due to assay interferences from the matrix | Selected Reaction Monitoring (SRM) |
| I need to screen candidate biomarkers in 100’s to 1,000’s of samples |
Parallel Reaction Monitoring (PRM)
|
Biomarker Selector
| Type of Biomarker | Intended Use | Our Solution |
|---|---|---|
| Diagnostic |
Early diagnosis
Differentiation of disease sub-types
|
TMT LC-MS3 TMTcalibrator SysQuant (tissue markers) |
| Prognostic |
Predicting disease progression
Guiding treatment selection
|
TMT LC-MS3 TMTcalibrator SysQuant (tissue markers) |
| Patient Stratification |
Patient selection for trial enrolment
Guiding treatment selection
|
TMT LC-MS3 TMTcalibrator |
| Pharmacodynamic | Monitoring of efficacy | TMTcalibrator |
| Already have protein biomarker candidates? | Validation in larger cohorts |
PRM
|